National Antiviral Service Cymru (NAVS)
The National Antiviral Service Cymru (NAVS) is co-ordinating the supply of treatments for COVID-19 for the most vulnerable individuals across Wales who have not been admitted to hospital.
Information for Healthcare Professionals
The following information and resources are aimed at healthcare professionals. Members of public can access information about the National Antiviral Service (NAVS) from this site.
Eligibility Criteria
The eligibility criteria are specified in the UK-wide Clinical Commissioning Policy and are available in this NAVS table.
Referral Portal
Healthcare professionals should use the information in the UK-wide Clinical Commissioning Policy to decide whether a patient is likely to be eligible for treatment. Where a healthcare professional considers a patient may be eligible for treatment, they can refer them for review by NAVS via an online portal. Patients cannot self-refer via this route, and should be directed to call NHS 111.
Patient Group Directions (PGDs)
The national COVID-19 treatment PGD templates are available below or on the WMIC publications pages. The sotrovimab PGD template is for adaptation by local health boards.
The national COVID-19 treatment PGD for oral antivirals is being run centrally for the whole of Wales within Cardiff and Vale University Health Board by the National Antiviral Service (NAVS Cymru). Copies of the PGDs are provided for information.
UK-wide Clinical Commissioning Policy Documents
The latest clinical commissioning policy documents can be accessed via the All Wales Therapeutics and Toxicology Centre (AWTTC ) COVID-19 therapies – alerts and advice page; under the ‘Neutralising monoclonal antibodies or antivirals’ section
Other useful resources
- Summary of Product Characteristics (SmPC) – Xevudy®
- Summary of Product Characteristics (SmPC) – Paxlovid®
- Summary of Product Characteristics (SmPC) – Lagevrio®
- NHS Medicines A to Z
- University of Liverpool COVID-19 Drug Interactions Checker
- NHS Specialist Pharmacy Services (SPS): medicines interactions with nirmatrelvir and ritonavir (Paxlovid®)
- PANORAMIC trial website